Ovacare is a food supplement for women, that consists of a natural mix of vitamins, metals, and antioxidants.
These ingredients act by enhancing the body’s antioxidative mechanisms and, thus, reducing oxidative stress, ensuring the necessary metabolic substrate for the ovarian tissue, and improving the effect of growth agents which promote folliculogenesis.
Ovacare contains, among others:
Folic acidis recommended for all women who are trying to conceive, with the aim to reduce the risk of harm to the embryo’s neural tube; miscarriage; embryo under-development, as well as the risk of foetal congenital heart disease, or even speech – language disability. Women who wish to gestate should have enough folic acid a month before getting pregnant.1,2,3*
Vitamin Ε (tocopherol)
Vitamin Ε and grapeseed extract are components with a strong antioxidant effect, offering protection to the egg (oocyte) from lesions caused to their DNA by free radicals; they also provide a shield to the egg’s cell membrane, which helps prevent early apoptosis while improving the egg’s mitochondrial function.4,5*
Melatonin may be helpful for women (aged 35 to 40 years old, mostly) who have low-quality eggs. Melatonin aids oocyte maturation, granulosa cell luteinisation and embryo growth, mediating the neuroendocrine metabolic pathways for the development of the brain. . It also reinforces inositoland folic acid effectiveness, having a crucial independent or synergistic action; melatonin can easily go through both cell membrane and blood-brain barrier directly absorbing free radicals that contain oxygen and nitrogen —including O2- and NO—and producing what is known as a “cascade reaction”.
Through this mechanism, melatonin improves oocyte quality and pregnancy outcomes in women with a history of low-quality eggs (oocytes).
Research has shown that clinical pregnancy and implantation percentages were higher in a group assigned to take adjuvant melatonin.Moreover, melatonin can regulate ovary function by activating multiple receptors (ΜΤ1, ΜΤ2) as well as signalling pathways over different types of target-cells, especially in theca cells and granulosa cells, thus improving progesterone production by the corpus luteum in women with fertility problems due to luteal phase disorders. This particular property is under research, even as a biomarker for ovarian reserve. Multicentric studies suggest lower risk for both abnormal embryo neural tube and gestation complications with short-term use of melatonin.6,7,8**
Myoinositol, according to research, is involved in various stages of human reproduction. It is a key intermediate molecule to second messengers, but also an essential component of cell membrane phospholipids involved in several biological processes. Its unique chemical structure allows myoinositol to “enter” and “exit” cells, playing a crucial role. G protein coupled receptors involved in ΡΙΡ2—Phosphatidylinositol Biphosphate—pathway, end producing inositol triphosphate (IP3) making it soluble and easily diffusible inside the cytoplasm. Increased myoinositolconcentration in follicular fluid appears to benefit follicle maturation and is indicative of high-quality eggs (oocytes). Myoinositol has great effectiveness in metabolic and hormonal disorders caused by Polycystic Ovary Syndrome, related to subfecundity, also inducing hormonal balance at the productive phase of women’s menstrual cycles.9,10**
A-lipoic acid is a strong antioxidant, which helps to protect female reproductive organs. It is endogenously produced and reinforces the production of other antioxidants, glutathione included. Among its properties are immediate elimination of reactive oxygen species (ROS) and a potential to react with other antioxidants, such as glutathione, coenzyme Q10 and vitamins E and C, thus improving their antioxidative action and contributing to the regeneration of oocytes’ cellular structures. A-lipoic acid helps carbohydrates metabolism and energy production, also creating an antioxidative complex, which is important for the proper function of cellular processes and restitution of the oocyte’s mitochondrial lesions; this is especially relevant for women who receive IVF and present fertilised eggs with abnormal morphology. It also has significant effect in overweight women with fertility problems who do not suffer from metabolic syndrome or Polycystic Ovary Syndrome.11,12**
Coenzyme Q10 is a natural antioxidant which occurs naturally in the body but is also available in foods or as a food supplement. It is found on the membrane of nearly every cell of the body and is necessary for the formulation of mitochondrial ATP, which is responsible for generating cell power. Regular embryo development until it reaches the blastocyst stage depends on the oocyte’s mitochondrial energy background, since mitochondria are uniquely contributing to the embryo formation. Most studies support coenzyme Q10 supplementary intake by women who will undergo in vitro fertilization, at a recommended dose of 600 mg daily, for about 2 months.13,14
L-Arginine is an activated amino-acid and helps improve blood circulation in ovarian stroma through vasodilation and its indirect, synergistic antioxidant effects.
L-Arginine is found in many foods and when taken for a certain amount of time, it enhances egg quality in women over the age of 35, while it doesn’t seem to increase the low number of ovarian follicles at the onset of their cycles.15
Two capsules, twice daily with meals, or according to the instructions given by your physician.
Each capsule contains: Each capsule contains: DL-α-Tocopherol: 21 mg (Vit E: 25 IU), Folic acid: 50 μg, Coenzyme Q10: 50 mg, Vitex agnus castus extract: 50 mg, Myoinositol: 125 mg, α-lipoic acid: 200 mg, Grape seed extract: 75 mg, Melatonin: 1 mg, L-Arginine hydrochloride: 60.4 mg (L-Arginine: 50 mg), Zinc citrate monohydrate: 23 mg (elemental Zn: 7 mg), Pyridoxine Hydrochloride: 1.7 mg (Vit B6: 1.7 mg).
Excipients: Microcrystalline cellulose: 50 mg, Magnesium Stearate: 10 mg, Silicon dioxide: 10 mg, HPMC Capsule N00: 118 mg
Do not exceed the recommended daily dose.
This product is not destined to prevent, treat, or cure human disease.
Consult your doctor if you are pregnant, lactating or under a medical regimen, or if you are facing a medical condition.
Keep away from children’s reach.
Poison Information Centre Telephone Number: +30 210 7793777
Weight per capsule: 795.15 mg
- Stock: 6
- BARDCODE: 8437014519045